Table 1.

Univariate and Multivariate analysis of disease-free survival rate in HNSCC patients.

Variables	HR (95%CI)	P	Adjusted HR (95%CI)	P
Overall survival
SMAD4 LOH and mutations
Wild type	Reference		Reference
LOH and/or mutations	1.95 (1.05–3.62)	0.034*	2.08 (1.10–3.92)	0.024*
SMAD4 expression
High	Reference		Reference
Low	4.30 (1.02–18.15)	0.047*	4.09 (0.93–18.00)	0.063
Disease-free survival
SMAD4 LOH and mutations
Wild type	Reference		Reference
LOH and/or mutations	2.08 (1.21–3.57)	0.008*	1.97 (1.14–3.42)	0.016*
SMAD4 expression
High	Reference		Reference
Low	4.43 (1.05–18.69)	0.043*	4.54 (1.03–20.12)	0.046*

Adjusted for age, gender, and clinical stage.

HR, hazard ratio; CI, confidence interval.