Table 2A.

Ability of the Individual Biomarkers in Discriminating CT-Negative and CT-Positive Patients in TBIs of All Severities (All, n = 160; CT-Negative, n = 65; CT-Positive, n = 95)

	Mann U CT+ vs. CT−	AUC (95%CI)	J (%SP/%SE; cut off)	%SP @ 100%SE (cut off)	pAUC (95%CI)	%SP/ 90–100%SE (cut off)
GFAP	< 0.001	0.822 (0.757–0.881)	0.52 (92.3/60; 2690)	13.8 (66.62)	3.26 (2.06–4.77)	41.5/93.7 (243)
NF-L	< 0.001	0.817 (0.748–0.877)	0.55 (83.1/71.6; 20.25)	6.2 (4.43)	2.20 (1.06–4.01)	40/90.5 (8.79)
tau	< 0.001	0.781 (0.702–0.852)	0.51 (80/70.5; 3.09)	4.6 (0.29)	1.93 (1.0–3.20)	23.1/94.7 (0.91)
Aβ40	< 0.001	0.680 (0.594–0.760)	0.36 (72.3/63.2; 19.9)	0 (-)	1.17 (0.51–2.3)	12.3/98.9 (6.72)
IL-10	< 0.001	0.676 (0.592–0.761)	0.30 (76.9/52.6; 0.87)	4.6 (0.14)	1.82 (0.91–3.06)	20.0/96.8 (0.21)
H-FABP	< 0.001	0.666 (0.582–0.751)	0.34 (50.8/83.2; 4480)	1.5 (1625.05)	1.33 (0.38–2.90)	30.8/90.5 (3760)
Aβ42	0.018	0.610 (0.519–0.692)	0.29 (76.9/51.6; 19.4)	1.5 (2.92)	0.54 (0.09–1.13)	6.2/96.8 (4.90)
S100B	0.072	0.584 (0.491–0.667)	0.20 (81.5/38.9; 141)	0 (-)	0.57 (0.12–1.35)	4.6/97.9 (11.5)