Heat map representation of DEGs and miRNAs between MTX-sensitive and MTX-resistant HT-29 cell lines. (A) Heat map of DEGs between 3MTX-sensitive HT-29 cell lines and 3MTX-resistant HT-29 cell lines. The red color represents low mRNA expression level, and the blue color represents high mRNA expression level. (B) Heat map representation of differently expressed miRNAs between MTX-sensitive HT-29 cell lines and MTX-resistant HT-29 cell lines. The red color represents low miRNA expression level, and the green color represents high mRNA expression level. DEGs, differently expressed genes; miRNA, microRNA; MTX, methotrexate.