Table I.
Patients and characteristics of the lesion.
| Groups | |||
|---|---|---|---|
| Characteristics | Nicorandil (n=32) | Placebo (n=33) | P-value |
| Age, in years | 60.0±10.0 | 61.8±9.7 | 0.466 |
| Male, n (%) | 21 (65.6) | 21 (63.6) | 0.869 |
| BMI, kg/m2 | 26.7±4.1 | 26.0±3.3 | 0.459 |
| Cardiovascular risk factors, n (%) | |||
| Hypertension | 23 (71.9) | 22 (66.7) | 0.655 |
| Diabetes mellitus | 8 (25) | 11 (34.4) | 0.468 |
| Hyperlipidemia | 12 (37.5) | 13 (39.4) | 0.878 |
| Smoking | 16 (50) | 15 (45.5) | 0.719 |
| Cr, µmol-/l | 72.91±11.63 | 69.94±17.75 | 0.430 |
| BUN, mg/dl | 5.22±1.88 | 8.89±15.93 | 0.198 |
| Previous MI, n (%) | 3 (9) | 3 (9) | 0.968 |
| Number of vessels occluded | 1.33±0.58 | 1.33±0.58 | 1.000 |
| EF, % | 62.8±6.4 | 60.1±8.7 | 0.157 |
| Clinical diagnosis, n (%) | |||
| MI | 5 (15.6) | 3 (9.1) | 0.431 |
| UA | 28 (84.4) | 30 (90.9) | 0.431 |
| Quantitative coronary angiography | |||
| Percent diameter stenosis, % | 89.3±7.1 | 87.0±7.5 | 0.236 |
| Vessel undergoing PCI, n | |||
| Left anterior descending artery | 21 | 19 | 0.681 |
| Left circumflex artery | 3 | 4 | 0.726 |
| Right coronary artery | 8 | 10 | 0.468 |
| Vessel diameter, mm | 23.06±7.52 | 26.79±9.04 | 0.07 |
| Therapy, % | |||
| Aspirin | 100 | 100 | 1.000 |
| Clopidogrel | 90.9 | 93.8 | 0.378 |
| ACEI | 93.75 | 93.94 | 0.975 |
| ARB | 6.25 | 6.06 | 0.975 |
| β-blocker | 100 | 100 | 1.00 |
| Statin | 100 | 100 | 1.00 |
| Glycoprotein IIb/IIIa inhibitor | 9.1 | 6.2 | 0.623 |
Data are expressed as mean ± SD, n (%), or median (interquartile range). BMI, body mass index; Cr, creatinine; BUN, blood urea nitrogen; MI, myocardial infarction; EF, ejection fraction; UA, unstable angina; ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor blocker; PCI, percutaneous coronary intervention. The t-test or χ2 test was used to assess the significance of the differences between the two groups.