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. 2019 Nov 9;16(12):1621–1630. doi: 10.7150/ijms.38502

Figure 5.

Figure 5

A: Amlodipine (3 × 10-7 M)-induced vasodilation in isolated endothelium-denuded rat aortae precontracted with the Rho-kinase activator sodium fluoride (NaF, 8 × 10-3 M) or the protein kinase C activator phorbol 12,13-dibutyrate (PDBu, 10-6 M). Data (N = 8) are shown as the mean ± SD and expressed as the percentage of maximal contraction induced by NaF or PDBu. N represents the number of isolated rat aortae. *P < 0.05 and †P < 0.001 versus PDBu. B and C: Effect of pretreatment with lipid emulsion (Intralipid, LE) on the vasodilation induced by amlodipine (3 × 10-7 M) in isolated endothelium-denuded rat aorta precontracted with NaF (8 × 10-3 M, B) or PDBu (10-6 M, C). Data (N = 8) are shown as the mean ± SD and expressed as the percentage of maximal contraction induced by NaF or PDBu. N represents the number of isolated rat aortae. *P < 0.05, #P <0.01 and †P < 0.001 versus control.