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. 2019 Dec 6;10:2725. doi: 10.3389/fmicb.2019.02725

TABLE 1.

Zika virus peptide inhibitors.

Inhibitor Sequence Testing model Cell lines IC50 (μM) CC50 (μM) References
Peptide Z2 MAVLGDTAWDF in vitro BHK21 cells 1.75 ± 0.13 Yu et al. (2017)
GSVGGALNSLG 3.69 ± 0.27
KGIHQIFGAAF Vero cells
P5 GQASNGVFVIH in vitro Vero cells 3.27 Chen et al. (2017)
WGKFDSFGIAV
Ev37 GLINEKKVQQYLDE in vitro Huh-7 cells Li et al. (2019)
KLPNGVVKGALKSL
VHKAAKNQNLCAF
NVDTVGMCDADCK
RQGKAKGVCHGT
KCKCDVELSYKK
Aprotinin in vitro 0.07 ± 0.012 Shiryaev et al. (2017)
Acyl-KR-aldehyde 0.208 Li et al. (2017d)
AH-D peptide SGSWLRDVWDWIC in vivo In mouse 0.0119 Cho et al. (2009), Jackman et al. (2018)
TVLTDFKTWLQSKL
FFAAP FFAAP in vitro Human JEG-3 cells Vero cells Margueron and Reinberg (2011), Di Croce and Helin (2013), Kim et al. (2015), Vasireddi et al. (2019)
ZMP STE24 in vitro T98-G cells Fu et al. (2017)