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. 2019 Dec 6;13:1310. doi: 10.3389/fnins.2019.01310

FIGURE 2.

FIGURE 2

(A) Domain structure of TDP-43. Numbers refer to amino acid positions. NLS is nuclear localization signal, NES is nuclear export signal, RRM1 and RRM2 are RNA recognition motifs. Prion-like protein (PLP) domain spans from amino acids 274–414. ALS associated mutations are clustered in the glycine-rich region. (B) Domain structure of the FUS protein. Numbers refer to amino acid positions. NLS is nuclear localization signal, NES is nuclear export signal, RRM is the RNA recognition motif, ZnF is the Zinc-Finger domain. Prion-like protein domains span from amino acids 1–239 and 391–407. A cluster or ALS associated mutations occur within the nuclear localization signal with others spread throughout the gene.