Table 2.

Effect of Rapamycin and Dietary Restriction on the Lifespan of Various Genetic Mouse Models

Mouse Model	Effect on Lifespan		Reference
	Rapa	DR
Amyotrophic lateral sclerosis (H46R/H48Q)	No effect	14% increase	(26)
Cancer prone (Rb+/-)	9%–14% increase	No effect	(27,28)
Cancer prone (p53-/-)	No effect	>70% increase	(29,30)
Genetically obese (ob/ob & db/db)	18%–23% decrease	>50% increase	(31,32)
Disruption of Circadian clock (Bmal1-/-)	50% increase	25% decrease	(33,34)
Growth hormone receptor knockout	5%–8% decrease	No effect	(23,35)