Fig. 3.

Regulatory roles and expression of lncRNAs in T cells of RA

BZRAP1, whose role in immune cells is not identified, is remarkably upregulated after knocking down LINC01882. MAP2K4, mediating the response of cells to cytokine signalling and stress, and ZEB1, coding the transcription factor that inhibits the expression of IL-2 in T cells, are downregulated by LINC01882 knockdown [53]. The expression of LINC01882, lncRNA LOC100652951 and LOC100506036 were remarkably increased in T cells from RA patients, LOC100506036 regulates IFN-γ, nuclear factor and SMPD1 to activate T cells [55–57].