Table 1.
LncRNA expression traits in other cellular components of RA
| LncRNA | Expression | Sample | Pathway | Functional role | Related gene | Reference |
|---|---|---|---|---|---|---|
| lncRNA NTT | Up | THP-1 cells (human monocytic leukaemia cell line) | C/EBP regulating | Regulating inflammation in monocytes | C/EBP | [61] |
| lncRNA-AF085935 | Up | Serum of RA patients associated with HCV | IL-10, IL-17 expression increasing | Detecting early RA associated with HCV | HCV RNA | [62] |
| GAS5 | Down | CD4 T cells and B cells obtained from RA and SLE patients | Regulated GR transcriptional activity through its decoy RNA ‘GRE’ | Regulating effect on autoimmunity, inflammation and infectious diseases. | GRE | [63] |
| HOTAIR | Up | Serum exosome and blood mononuclear cells in RA patients | Repressing the activation of MMP-13 and MMP-2; inhibiting miR-138 and NF-κB | Alleviating RA | MMP-13 MMP-2 | [67, 69, 70] |
| H19 | Up | Synovial tissue in RA and OA patients; isolated synovial fibroblasts and macrophages | None | Be a tumour markerRelating to TIMP-2 in synovial fibroblasts | PI3k ERK-1/2 | [73] |
| HOTAIR and lncRNA-Cox2 | Up | Serum from RA patients | None | Discriminating RA patients from healthy folks | IL-6 and MMP-9 | [71] |
GR: glucocorticoid receptor; GRE: glucocorticoid response element.