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ADCY1 is a main regulator of the cAMP signaling pathway. ADCY1 can catalyse ATP to generate cyclic adenosine 3', 5'-monophosphate (cAMP), and then the 3', 5'-cAMP will degrade into 5'-cAMP by cyclic nucleotide phosphodiesterases. As a second messenger, cAMP participate in many important cellular activities. It can regulate its downstream effectors to have an influence on DNA damage, cell apoptosis and cell proliferation, which is linked with drug resistance.
