Figure 2.

ADCY1 can participate in abundant cellular signaling pathways and contributes to physical behavior through the regulation of cAMP. ADCY1 can catalyze the formation of cAMP to modulate a series of signaling pathways. The major downstream effectors of cAMP including CNGs, EPACs and PKAs, which can regulate various cellular activities. And the mistaken control of ADCY1 as the upstream modulator can contribute to complex disorder of these regulation. The complicated signaling pathway indicate the probable association between ADCY1 and lung cancer.