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cAMP can regulate multidrug-resistance in lung cancer through the regulation of plenty of downstream effectors, which is participating in the cAMP signaling pathway such as the classical PKA and CREB or some other useful effectors. Through the regulation of these downstream effectors, cAMP can modulate cell apoptosis, cell survival, cell growth, cell cycle and cell proliferation which will have an effect on multidrug-resistance in lung cancer treatment.
