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. 2019 Nov 1;10(27):6848–6857. doi: 10.7150/jca.36614

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cAMP can control multidrug resistance in lung cancer and other malignant tumors through the regulation of particular lncRNAs involving in different signaling pathways, which is of great value in clinical treatment for lung cancer therapy. cAMP can modulate CREB and PKA to have an influence in the lncRNA such as lncRNA HULC and lncRNA 00473. Through the regulation of lncRNA, cAMP can also make a connection with cell apoptosis and cell survival, which is associated with drug-resistance significantly.