Table 2.
Altered signaling pathways in NHOKs by EC aerosols.
| Ingenuity Canonical Pathways | -log(p) | Number of Molecules | Molecules |
|---|---|---|---|
| Unfolded protein response | 5.48E00 | 16 | DDIT3,HSPA14,ERN1,INSIG1,XBP1,CEBPB,DNAJB9,HSPA2,HSPA1L,CEBPG,HSPA8,SEL1L,SYVN1,HSPA4,PPP1R15A,ATF4 |
| Glucocorticoid Receptor Signaling | 4.25E00 | 42 | ICAM1,TGFBR1,HSPA14,POU2F2,SOS2,GTF2H2,KRAS,HSPA1L,TSC22D3,IL1R2,HSPA4,IKBKB,GTF2B,NFKBIA,NFAT5,HSP90AB1,ANXA1,TGFB2,FKBP5,SERPINE1,ADRB2,CREBZF,CXCL8,CDKN1C,NRAS,TAF5L,CREBBP,SMARCE1,CEBPB,PPP3CC,STAT3,HSPA2,HSPA8,FOS,RRAS2,TAF5,IL1RN,HSP90AA1,NFATC2,IL1B,PLAU,PTGS2 |
| Protein Ubiquitination Pathway | 3.62E00 | 38 | B2M,USP24,CRYAB,USP45,HSPA14,CDC20,UBE2N,USP53,ANAPC10,CDC23,DNAJA1,HSPA1L,PAN2,HSPA4,HSP90AB1,UBE2B,USP13,NEDD4L,PSMC2,NEDD4,USP15,USP9X,MDM2,HSPD1,DNAJB9,HSPA2,HSPA12A,SKP2,USP31,HSPA8,USP32,CUL2,HSPA13,ANAPC5,HSP90AA1,DNAJB6,USP9Y,USP25 |
| B Cell Receptor Signaling | 3.10E00 | 27 | RAC2,POU2F2,SOS2,INPPL1,KRAS,BCL6,PTK2,IKBKB,NFKBIA,NFAT5,CFL2,ATF4,NRAS,PRKCQ,EGR1,CREBBP,PPP3CC,ATF2,SYNJ2,CALM1 (includes others),RRAS2,DAPP1,BCL10,PAG1,NFATC2,MAP2K3,MAP3K8 |
| Molecular Mechanisms of Cancer | 2.98E00 | 47 | FZD10,RAC2,BMP4,TGFBR1,FZD3,ARHGEF7,BMP2,SOS2,CTNNA1,KRAS,FZD1,CDKN2B,CCND1,PTK2,NFKBIA,TGFB2,HIPK2,CDC25A,PMAIP1,NRAS,GNAS,PRKCQ,PAK6,TFDP1,CYCS,ITGA2,PTCH1,CREBBP,SMAD7,CDK6,MDM2,AURKA,FZD8,FOS,CCNE1,CCND2,RRAS2,LEF1,FZD5,MAP2K3,CFLAR,BMP6,NOTCH1,ARHGEF10,FNBP1,GNAL,WNT5A |
| Cyclins and Cell Cycle Regulation | 2.86E00 | 15 | HDAC9,HDAC4,TFDP1,PPP2CA,WEE1,CDK6,CCND1,CDKN2B,SKP2,CCNB1,CCNE1,CCND2,TGFB2,PPP2R1B,CDC25A |
| Cell Cycle: G1/S Checkpoint Regulation | 2.79E00 | 13 | HDAC9,HDAC4,TFDP1,CDK6,MDM2,CCND1,CDKN2B,SKP2,NRG1,CCNE1,CCND2,TGFB2,CDC25A |
| TGF-β Signaling | 2.74E00 | 16 | BMP4,NRAS,TGFBR1,BMP2,CREBBP,SOS2,SMAD7,KRAS,TGIF1,INHBA,FOS,RRAS2,TGFB2,MAP2K3,SERPINE1,TFE3 |
| ILK Signaling | 2.73E00 | 27 | SNAI2,FN1,PPP2CA,BMP2,MYH11,RICTOR,CCND1,VEGFA,PTK2,NCK2,TGFB1I1,CFL2,PPAP2B,ATF4,IRS2,ITGB5,NACA,CREBBP,FERMT2,VEGFC,ATF2,DOCK1,FOS,LEF1,PTGS2,PPP2R1B,FNBP1 |
| PPAR Signaling | 2.58E00 | 16 | NRAS,PPARD,CREBBP,SOS2,KRAS,IL1R2,IKBKB,FOS,IL18,NFKBIA,RRAS2,HSP90AB1,IL1RN,IL1B,HSP90AA1,PTGS2 |
| NRF2-mediated Oxidative Stress Response | 2.55E00 | 26 | NQO2,GCLC,KRAS,DNAJA1,CUL3,HMOX1,SCARB1,ATF4,GCLM,FKBP5,CBR1,NRAS,PRKCQ,NQO1,CREBBP,HERPUD1,JUNB,DNAJB9,BACH1,FOS,RRAS2,STIP1,MAP2K3,SQSTM1,DNAJB6,ABCC4 |
| Ephrin Receptor Signaling | 2.42E00 | 25 | RAC2,PTPN13,SOS2,LIMK2,KRAS,VEGFA,PTK2,NCK2,GNB4,CFL2,EFNA5,ATF4,ACTR2,NRAS,GNAS,PAK6,ITGA2,CREBBP,VEGFC,STAT3,EFNA1,ATF2,RRAS2,EPHB3,GNAL |
| Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes | 2.37E00 | 14 | NRAS,TGFBR1,SOS2,KRAS,PPP3CC,IKBKB,CALM1 (includes others),FOS,NFAT5,RRAS2,NFKBIA,BCL10,TGFB2,NFATC2 |
| CDP-diacylglycerol Biosynthesis I | 2.12E00 | 5 | TAMM41,GPAM,AGPAT5,ABHD5,AGPAT9 |
| Regulation of the Epithelial-Mesenchymal Transition Pathway | 2.10E00 | 25 | FZD10,ID2,SNAI2,TGFBR1,FZD3,SOS2,KRAS,FZD1,FGFR4,TGFB2,HMGA2,TWIST2,NRAS,JAG2,EGR1,STAT3,FZD8,RRAS2,LEF1,FZD5,MAP2K3,FGFRL1,JAG1,NOTCH1,WNT5A |
| PI3K/AKT Signaling | 1.99E00 | 18 | NRAS,PPP2CA,SOS2,ITGA2,MDM2,KRAS,INPPL1,CCND1,EIF4E,SYNJ2,IKBKB,NFKBIA,RRAS2,HSP90AB1,HSP90AA1,MAP3K8,PTGS2,PPP2R1B |
| Human Embryonic Stem Cell Pluripotency | 1.96E00 | 19 | FZD10,TGFBR1,GNAS,BMP4,FZD3,BDNF,BMP2,SMAD7,FZD1,INHBA,S1PR3,FZD8,FGFR4,TGFB2,FZD5,LEF1,FGFRL1,BMP6,WNT5A |
| NF-κB Signaling | 1.93E00 | 23 | AZI2,TGFBR1,BMP4,PRKCQ,NRAS,BMP2,UBE2N,CREBBP,TNFAIP3,KRAS,TANK,IL1R2,IKBKB,IL18,GHR,RRAS2,NFKBIA,IL1RN,BCL10,FGFR4,IL1B,MAP3K8,FGFRL1 |
| PAK Signaling | 1.90E00 | 14 | NRAS,PAK6,ARHGEF7,SOS2,ITGA2,KRAS,MYLK,LIMK2,PTK2,NCK2,RRAS2,CFL2,EPHB3,MYL12A |
| Phosphatidylglycerol Biosynthesis II | 1.88E00 | 5 | TAMM41,GPAM,AGPAT5,ABHD5,AGPAT9 |
| IL-6 Signaling | 1.85E00 | 17 | CXCL8,SOCS3,NRAS,SOS2,KRAS,STAT3,CEBPB,VEGFA,IL1R2,FOS,IKBKB,IL18,RRAS2,NFKBIA,IL1RN,IL1B,MAP2K3 |
| IL-8 Signaling | 1.80E00 | 24 | RAC2,CXCL8,NRAS,ICAM1,GNAS,PRKCQ,HBEGF,VEGFC,LIMK2,KRAS,PLD6,CCND1,PTK2,VEGFA,IKBKB,HMOX1,FOS,GNB4,CCND2,RRAS2,PTGS2,FNBP1,ITGB5,IRAK2 |
| Triacylglycerol Biosynthesis | 1.79E00 | 7 | GPAM,AGPAT5,ABHD5,PPP2R2D,PPAP2B,AGPAT9,ELOVL6 |
| IL-10 Signaling | 1.65E00 | 11 | IL1R2,HMOX1,IKBKB,SOCS3,FOS,IL18,NFKBIA,IL1RN,IL1B,MAP2K3,STAT3 |
| Sphingosine and Sphingosine-1-phosphate Metabolism | 1.64E00 | 3 | ASAH2B,NAAA,SGPP2 |
| HGF Signaling | 1.63E00 | 15 | PRKCQ,NRAS,SOS2,ITGA2,KRAS,STAT3,CCND1,ATF2,PTK2,FOS,DOCK1,ELF3,RRAS2,MAP3K8,PTGS2 |
| T Cell Receptor Signaling | 1.59E00 | 14 | PRKCQ,NRAS,SOS2,KRAS,PPP3CC,IKBKB,CALM1 (includes others),FOS,NFKBIA,NFAT5,RRAS2,BCL10,PAG1,NFATC2 |
| p53 Signaling | 1.53E00 | 14 | HDAC9,PMAIP1,GADD45B,TP63,SNAI2,PIAS1,MDM2,CCND1,CCNG1,CCND2,STAG1,THBS1,HIPK2,DRAM1 |
| PTEN Signaling | 1.48E00 | 16 | RAC2,TGFBR1,NRAS,SOS2,ITGA2,INPPL1,KRAS,CCND1,SYNJ2,PTK2,IKBKB,MAGI1,RRAS2,GHR,FGFR4,FGFRL1 |
| CD40 Signaling | 1.45E00 | 10 | TANK,IKBKB,FOS,ICAM1,NFKBIA,PTGS1,TNFAIP3,MAP2K3,STAT3,PTGS2 |