Table 2.
Univariate and multivariate analyses of prognostic factors for OS and PFS.
| OS | PFS | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Univariate | Multivariate | Univariate | Multivariate | ||||
| HR (95%CI) | p | R (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | |
| Pure GGO nodules | ||||||||
| No | 1 | 1 | 1 | * | * | |||
| Yes | 0.464 (0.220-0.977) | 0.043 | 1.417 (0.649-3.094) | 0.381 | 0.451 (0.202-1.010) | 0.053 | * | * |
| Age | ||||||||
| ≤60 | 1 | 1 | 1 | * | * | |||
| >60 | 1.241 (1.052-1.463) | 0.010 | 1.372 (1.158-1.624) | <0.001 | 1.034 (0.860-1.244) | 0.722 | * | * |
| Gender | ||||||||
| Female | 0.744 (0.616-0.899) | 0.002 | 1.148 (0.876-1.504) | 0.317 | 1.182 (0.964-1.449) | 0.109 | * | * |
| Male | 1 | 1 | 1 | * | * | |||
| Histological subtype | ||||||||
| Adenocarcinoma | 1 | 1 | 1 | * | * | |||
| Squamous | 1.156 (0.965-1.385) | 0.115 | 0.801 (0.655-0.979) | 0.031 | 0.871 (0.711-1.068) | 0.184 | * | * |
| SCLC | 1.598 (1.197-2.133) | 0.001 | 0.838 (0.612-1.148) | 0.270 | 1.137 (0.807-1.601) | 0.463 | * | * |
| Others | 0.993 (0.698-1.414) | 0.045 | 1.081 (0.656-1.780) | 0.760 | 0.776 (0.514-1.172) | 0.228 | * | * |
| Smoking index | ||||||||
| Never | 1 | 1 | 1 | * | * | |||
| Former | 1.512 (1.167-1.960) | 0.002 | 1.121 (0.805-1.561) | 0.500 | 1.306 (0.981-1.738) | 0.067 | * | * |
| Current | 1.66 (1.134-1.645) | 0.001 | 1.007 (0.772-1.314) | 0.959 | 1.053 (0.861-1.288) | 0.615 | * | * |
| Tumor size | ||||||||
| ≤3cm | 1 | 1 | 1 | 1 | ||||
| >3cm | 1.909 (1.606-2.269) | <0.001 | 1.281 (1.051-1.562) | 0.014 | 1.758 (1.452-2.128) | <0.001 | 1.278 (1.029-1.578) | 0.027 |
| Lymph node metastasis | ||||||||
| No | 1 | 1 | 1 | 1 | ||||
| Yes | 2.904 (2.442-3.455) | <0.001 | 1.670 (1.299-2.146) | <0.001 | 2.297 (1.901-2.774) | <0.001 | 1.428 (1.082-1.884) | 0.012 |
| Pathological TMN stage | ||||||||
| Ⅰ | 1 | 1 | 1 | 1 | ||||
| II | 2.416 (1.907-3.060) | <0.001 | 1.541 (1.135-2.090) | 0.006 | 2.035 (1.587-2.610) | <0.001 | 1.345 (0.969-1.865) | 0.076 |
| III | 4.219 (3.396-5.241) | <0.001 | 2.264 (1.615-3.174) | <0.001 | 3.063 (2.431-3.860) | <0.001 | 1.759 (1.217-2.543) | <0.001 |
| Differential degree | ||||||||
| Well | 1 | 1 | 1 | 1 | ||||
| Moderate | 3.420 (2.215-5.280) | <0.001 | 2.220 (1.406-3.505) | 0.001 | 2.197 (1.480-3.261) | <0.001 | 1.524 (1.017-2.286) | 0.041 |
| Poor | 4.302 (2.777-6.663) | <0.001 | 2.514 (1.580-4.002) | <0.001 | 3.039 (2.044-4.519) | <0.001 | 1.934 (1.282-2.917) | 0.002 |
| Unknown | 2.527 (1.497-4.264) | 0.001 | 1.843 (0.986-3.444) | 0.055 | 1.641 (0.976-2.759) | 0.062 | 1.346 (0.798-2.269) | 0.226 |
Abbreviation: OS= overall survival; PFS=progression-free survival; HR=hazard ratio; CI=confidence interval; SCLC=small cell lung cancer.