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. 2019 Nov 1;15(13):2815–2829. doi: 10.7150/ijbs.31781

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Spexin inhibited gluconeogenesis in a dose- and time dependent manner in an IR cell model. (A) Spexin was mainly expressed in the cytoplasm of the HepG2 cells. The spexin expression was significantly reduced in HepG2-IR cells as compared with that in the control group. (B) HepG2-IR cells and primary mouse hepatocytes were cultured with different concentrations of spexin. The higher the concentration of spexin was correlated to a lower glucose concentration in the supernatant. (C) Endogenous glucose production was significantly decreased in HepG2-IR and primary mouse hepatocytes -IR cells that were cultured with 1 μg/mL spexin for 18 h, 24 h, 30 h, and 36 h compared with that of the control group.* P < 0.05.