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. 2019 Nov 1;15(13):2815–2829. doi: 10.7150/ijbs.31781

Figure 5.

Figure 5

Expression of important transcription factors and key enzymes in gluconeogenesis. (A, B, C, D) Spexin dose-dependently inhibited the expression of FoxO1, PGC-1α, PEPCK, G-6-Pase mRNA. (E) The spexin treatment increased the p-FoxO1 Ser256/FoxO1 ratio. (F) The protein expression of FoxO1, PGC-1α, HNF-4, PPAR-α, PEPCK, and G-6-Pase. (G) Knockdown of endogenous FOXO1 in the HepG2-IR cells decreased the glucose contents and co-cultivation of spexin did not further reduce glucose contents. * P < 0.05, # P > 0.05.