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. 2019 Dec 6;10:2883. doi: 10.3389/fimmu.2019.02883

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Copyright © 2019 Egu, Kugelmann and Waschke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Split desmosomes after incubation with PV-IgG. (A) Electron-micrograph of split desmosomes with reduced plaques as well as reduced keratin associations. Arrows indicate split desmosomes. Scale bar: 500 nm. (B) Length of split desmosomes as compared to normal controls. (C) Ratio of split desmosomes expressed as percentage of total desmosomes in the vicinity of blister. n = 3. *P < 0. 05 vs. control.