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. Author manuscript; available in PMC: 2019 Dec 13.
Published in final edited form as: Mol Neurobiol. 2015 Aug 23;53(7):4563–4581. doi: 10.1007/s12035-015-9395-8

Fig. 3.

Fig. 3

LSD1 inhibition blocked rod photoreceptor development. a, b Rhodopsin (green) expression in PN1 retinal explants cultured for 8 days in the presence of LSD1 inhibitors, TCP (a) or pargyline (b), with nuclear counterstained with Hoechst33358 (blue). c. Rhodopsin expression by RT-PCR in PN1 retinal explants cultured for 8 days in the presence of IGF1 or alone and in combination with LSD1 inhibitor TCP (*p<0.01 vs. control; *** p<0.0001 vs. control). d, e Changes in rhodopsin expression caused by TCP were not due to changes in cell death or cell proliferation. TUNEL labeling (green) for apoptotic cell in 8 days control or TCP-treated explants culture (d). BrdU incorporation (green) in 5 days control or TCP-treated explants culture (e). Nuclear counterstained with Hoechst33358 (blue)