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. 2019 Dec 9;10:405–415. doi: 10.2147/JBM.S189176

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© 2019 Hawkins et al.

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Presence of platelet autoantibodies correlates with development of thrombocytopenia. An IgG antibody reactive with autologous platelets (red bars) was detected in PTP patient serum collected on Days 7, 8, 11, 13, 23 post-surgery when patient had thrombocytopenia (black line). Serum collected Day 133 post-surgery following platelet count recovery showed no autoantibodies. Strong IgG antibodies against HPA-1a/1a normal donor platelets (blue bars) were detected in sera from each time point. Values shown are flow cytometry median fluorescence intensity (MFI). Dashed line is MFI cut-off for antibody positive results.

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