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Cartoon depiction of autoantibody formation through somatic hypermutation of B-cell genes encoding IgG HPA-1a alloantibody (A). Autoantibody can bind platelets that are HPA-1a+ (B) or platelets that are. HPA-1a-negative (D), whereas HPA-1a antibodies can bind only HPA-1a+ platelets (A), but cannot bind and clear HPA-1a-negative platelets (C).
