Table 1. Multivariate Cox regression analysis in training and validation datasets.
| Parameter | GSE49711 | GSE16476 | TARGET-NBL | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | p-value | 95% CI | HR | p-value | 95% CI | HR | p-value | 95% CI | |
| pCRS | 1.579 | 4.70E–05 | 1.267–1.967 | 1.665 | 6.79E–03 | 1.151–2.409 | 3.848 | 1.76E–05 | 2.08–7.118 |
| Gender | 0.629 | 0.023 | 0.421–0.938 | 1.147 | 0.71 | 0.558–2.356 | 0.856 | 0.591 | 0.485–1.51 |
| Age group | 1.543 | 0.185 | 0.813–2.930 | 4.638 | 0.027 | 1.193–18.032 | 0.939 | 0.958 | 0.091-9.666 |
| MYCN status | 0.935 | 0.948 | 0.127–6.914 | 1.249 | 0.558 | 0.593–2.632 | 1.639 | 0.157 | 0.826–3.252 |
| High Risk | 4.858 | 7.25E–04 | 1.943–12.149 | NA | NA | NA | 6.191 | 0.156 | 0.497–77.057 |
| INSS stage | 1.202 | 0.203 | 0.906–1.594 | 1.871 | 0.108 | 0.873–4.011 | NA | NA | NA |
| Histology | NA | NA | NA | NA | NA | NA | 1.417 | 0.721 | 0.209–9.594 |
| MKI | NA | NA | NA | NA | NA | NA | 1.236 | 0.254 | 0.859–1.778 |
Notes.
- HR
- hazard ratio
- CI
- confidence interval
Bole type emphasizes p < 0.05.