Table 2.

Multivariable logistic regression analysis of the characteristics of NM compared with SSM stratified by T1 and T2 Breslow thickness^*

Variable	Breslow thickness
	T1: ≤1 mm (n = 4229)		T2: 1.1–2.0 mm (n = 2232)
	OR (95% CI)	P †	OR (95% CI)	P †
Sex
Female	1.00 (Ref)		1.00 (Ref)
Male	1.35 (0.95 to 1.91)	.09	1.16 (0.94 to 1.44)	.17
Age, y
≤50	1.00 (Ref)		1.00 (Ref)
>50	1.03 (0.73 to 1.46)	.85	1.06 (0.85 to 1.32)	.62
Log Breslow thickness, mm	13.06 (6.59 to 25.91)	<.001	7.74 (4.59 to 13.05)	<.001
Anatomic site
Lower extremities	1.00 (Ref)		1.00 (Ref)
Head/neck	2.16 (1.27 to 3.69)	.005	1.42 (1.02 to 2.00)	.04
Trunk	1.14 (0.72 to 1.81)	.59	1.08 (0.82 to 1.42)	.60
Upper extremities	1.16 (0.71 to 1.91)	.56	1.56 (1.17 to 2.07)	.002
Ulceration
Absent	1.00 (Ref)		1.00 (Ref)
Present	1.37 (0.75 to 2.49)	.31	1.15 (0.89 to 1.47)	.28
Regression
Absent	1.00 (Ref)		1.00 (Ref)
Present	0.46 (0.29 to 0.72)	.001	0.45 (0.34 to 0.60)	<.001
Nevus remnants
Absent	1.00 (Ref)		1.00 (Ref)
Present	0.60 (0.42 to 0.85)	.004	0.57 (0.45 to 0.71)	<.001
Mitoses
Absent	1.00 (Ref)		1.00 (Ref)
Present	1.97 (1.33 to 2.93)	.001	2.43 (1.57 to 3.75)	<.001
Tumor spread (initial diagnosis)
Localized	1.00 (Ref)		1.00 (Ref)
Regional metastasis	1.77 (1.02 to 3.05)	.04	0.78 (0.60 to 1.01)	.06
Distant metastasis	21.35 (4.94 to 92.25)	<.001	1.33 (0.52 to 3.36)	.55

^*Multivariable analysis adjusted for all variables included in this table. CI = confidence interval; NM = nodular melanoma; SSM = superficial spreading melanoma.

^†All statistical tests are two sided.