Table I.
Main characteristics of the seven included cohort studies.
| Author, year | Origin of populations | Number of patients | Stage | Sample type | Detection method | Cut-off value | Outcome | Follow up (Month) | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|
| Lokeshwar et al, 2018 | USA | 75 | pT0-pT4 | Frozen tissue | qPCR | ROC curve | OS MFS | 23 | (22) |
| Kowalczyk et al, 2016 | Poland | 56 | pT1-pT3 | Frozen tissue | RT-qPCR (TaqMan) | - | OS | 28.8 | (23) |
| Tang and Hu, 2015 | China | 45 | - | Frozen tissue | RT-qPCR (SYBR) | X-tile algorithm | CSS | 58.4 | (24) |
| Vergho et al, 2014 | Germany | 103 | pT1-pT3 | Frozen tissue | RT-qPCR (TaqMan) | ROC curve | CSS | 68 | (25) |
| Vergho et al, 2014 | Germany | 37 | T3 | FFPE | RT-qPCR (TaqMan) | ROC curve | CSS | 152 | (26) |
| Faragalla et al, 2012 | Canada | 121 | pT1-pT3 | FFPE | RT-qPCR (TaqMan) | X-tile algorithm | OS DFS | 50 | (27) |
| Zaman et al, 2012 | USA | 36 | - | FFPE | RT-qPCR (TaqMan) | - | OS | - | (28) |
ROC, receiver operating curve; RT-qPCR, reverse transcription-quantitative PCR; qPCR, quantitative PCR; OS, overall survival; CSS, cancer-specific survival; MFS, metastasis-free survival; DFS, disease-free survival; FFPE, formalin-fixed and paraffin-embedded.