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. 2019 Dec 2;56(1):139–150. doi: 10.3892/ijo.2019.4931

Figure 2.

Figure 2

UNC5C inhibits the viability and invasion of breast cancer cells. (A) UNC5C-knockdown reduced UNC5C protein expression in SK-BR-3 and ZR-75–30 cells, and UNC5C-overexpression enhanced UNC5C protein expression in MDA-MB-231 cells. (B) MTT assay. UNC5C-knockdown promoted viability of the breast cancer cell lines SK-BR-3 and ZR-75-30. UNC5C-overexpression inhibited viability of the breast cancer line MDA-MB-231. ****P<0.0001. (C) UNC5C-knockdown in SK-BR-3 and ZR-75-30 cells leads to enhanced invasion, while UNC5C-overexpression in MDA-MB-231 cells leads to reduced invasion of breast cancer cells in the Transwell assay. Scale bar, 50 µm. *P<0.05, **P<0.01 vs. control cells. Data are expressed as the mean ± standard deviation. UNC5C, Unc-5 Netrin Receptor C; sh, short hairpin; Ctrl, control; OD, optical density.