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. 2019 Dec 2;56(1):139–150. doi: 10.3892/ijo.2019.4931

Figure 5.

Figure 5

Effects of PI3K/AKT, ERK and p38 MAPK inhibitors on MMP9 expression and the invasion of SK-BR-3 cells. (A) The upregulation of MMP9 induced by UNC5C-knockdown was decreased by the inhibitors. (B) The UNC5C-knockdown-induced increase in invasion was antagonized by the inhibitors. Scale bar, 50 µm. Significant differences were determined by one-way ANOVA followed by Tukey's post hoc test. **P<0.01, ****P<0.0001 vs. no inhibitors. UNC5C, Unc-5 Netrin Receptor C; sh, short hairpin; Ctrl, control; MMP, matrix metalloproteinase.