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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: Eur J Pharmacol. 2019 Nov 15;865:172806. doi: 10.1016/j.ejphar.2019.172806

Figure 6. Antiemetic effects of intraperitoneally-administered WIN55,212-2 against substance P (SP)-induced emesis in the least shrew.

Figure 6.

Different groups of shrews received either vehicle (0 mg/kg) or varying doses of WIN55,212-2, 30 min following an emetic dose of SP (50 mg/kg, i.p.). Emetic parameters were recorded for the next 30 min post emetic injection. The mean frequency of vomits (± S.E.M.) (graph A) and the percentage of animals vomiting (graph B) are presented. ** P < 0.01, *** P < 0.001, and **** P < 0.0001 versus 0 mg/kg control. N = 8-10 shrews/ group.