. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Eur J Pharm Biopharm. 2019 Sep 26;144:252–265. doi: 10.1016/j.ejpb.2019.09.023

Table 3.

Estimated coating thickness of citrate and simulated body fluids on nanoceria.

Sample	Sorbed ligand	Diameter of sorbed complex (nm)	Adsorbate molecule diameter (nm)	Coating thickness
Uncoated	Control	21.1	Control	Control
FaSSIF exposed ^a	Maleic acid	21.2	0.61	<< monolayer
SLF exposed ^a	Acetic acid	21.2	0.57	<< monolayer
FaSSGF exposed ^a	Taurocholic acid	21.3	1.1	≈ ¼ monolayer
Citrate coated ^a	Citric acid	21.4	0.72	≈ ½ monolayer
FeSSIF exposed ^a	Maleic acid	21.6	0.61	≈1 monolayer
FeSSGF exposed ^b	K-casein	Not applicable	Not applicable	1 to 2 layers

estimated from the weight of the coating for the average nanoceria particle diameter

estimated by assuming that Κ-casein adsorbed to the average nanoceria particle size and comparing the adsorbed weight to a closely packed (one layer) or randomly packed (two layers) structure.