Figure 7.

Preservation of retinal function by treatment with SRD005825. ERG was performed on dark-adapted, anesthetized T17M transgenic mice following 7 weeks of treatment with SRD005925 or vehicle, using an LKC Electrodiagnostic System to deliver flashes at –20 dB (0.025 cd·sec/m²), –10 dB (0.25 cd·sec/m²), and 0 dB (2.5 cd·sec/m²). Following 2 minutes of photobleaching, with constant white light, photopic ERG responses were recorded, and the response to 10-dB flashes is reported. (A) Representative wave forms of scotopic (at 0 dB) and photopic (10 dB) electroretinograms from SRD005825-treated and vehicle-treated mice. Male a, N = 12; SRD005825-treated females, N = 8; vehicle-treated males, N = 4; vehicle-treated females, N = 6. Error bars indicate standard deviations. P values indicated in the figure were determined by 2-way ANOVA using the Sidak method for multiple comparisons.