Table 2.

Pharmacokinetic Parameters of SRD005825

Dose Level (mg/kg)	Sex	Cmax Plasma (ng/g)	Cmax Plasma (nmole/g)	Cmax Retina (ng/g)	Cmax Retina (nmole/g)	t1/2 Retina (hour)
20	Male	1380	4.69	1410	4.79	0.854
20	Female	427	1.45	627	2.13	0.556
40	Male	5760	19.58	6970	23.70	1.12
40	Female	2740	9.32	2670	9.08	1.21
120	Male	27700	94.18	27700	94.18	4.24
120	Female	12500	42.50	8820	29.99	1.09

C_max, maximum concentration in plasma or retina after a single dose; t_1/2, observed elimination half-life.