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(A) 99mTc-labeled tilmanocept time–activity curves exhibited kinetic sensitivity to chronic kidney disease. Diabetic db/db mice (green, 4.9 wk; yellow, 7.3 wk; red, 13.3 wk) peaked within 2 min after injection. Nondiabetic db/m mouse (blue) peaked 18 min after injection. (B) Expanded view shows progressively faster accumulation with increasing age.
