Processing step	Reason	Options [suboptions]	Number of plausible options
Motion correction	Correct for head motion during scanning	• ‘Interpolation’ [linear or sinc] • ‘Reference volume’ [single or mean]	4
Slice timing correction	Correct for differences in acquisition timing of different slices	‘No’, ‘before motion correction’ or ‘after motion correction’	3
Field map correction	Correct for distortion owing to magnetic susceptibility	‘Yes’ or ‘no’	2
Spatial smoothing	Increase SNR for larger activations and ensure assumptions of GRF theory	‘FWHM’ [4 mm, 6 mm or 8 mm]	3
Spatial normalization	Warps an individual brain to match a group template	‘Method’ [linear or nonlinear]	2
High-pass filter	Remove low-frequency nuisance signals from data	‘Frequency cut-off’ [100 s or 120 s]	2
Head motion regressors	Remove remaining signals owing to head motion via statistical model	‘Yes’ or ‘no’ [if yes: 6/12/24 parameters or single time point ‘scrubbing’ regressors]	5
Haemodynamic response	Account for delayed nature of haemodynamic response to neuronal activity	• ‘Basis function’ [‘single-gamma’ or ‘double-gamma’] • ‘Derivatives’ [‘none’, ‘shift’ or ‘dispersion’]	6
Temporal autocorrelation model	Model for the temporal autocorrelation inherent in fMRI signals	‘Yes’ or ‘no’	2
Multiple-comparison correction	Correct for large number of comparisons across the brain	‘Voxel-based GRF’, ‘cluster-based GRF’, ‘FDR’ or ‘non-parametric’	4
Total possible workflows			69,120

FDR, false discovery rate; FWHM, full width at half maximum; GRF, Gaussian random field; SNR, signal-to-noise ratio.