Table 2. Sequence alignment of human and mouse constant region used to modify MHC-II restricted TCRs.

TCR chain	Sequence alignment
Alpha	Human	IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNS	60
	Mouse	IQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKTVLDMKAMDSKSNG	60
		****:******:*.:*.*.::********* **.:: :*..:*********::** ***.
	Human	AVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFR	120
	Mouse	AIAWSNQTSFTCQDIFK----ETNATYPSSDVPCDATLTEKSFETDMNLNFQNLSVMGLR	116
		*:****::.*:* : *:      :: :**.: .**..*.******* *********:*:*
	Human	ILLLKVAGFNLLMTLRLWSS	140
	Mouse	ILLLKVAGFNLLMTLRLWSS	136
		********************
Beta	Human	DLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQ	60
	Mouse	DLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQ	60
		**.:* **:*::****:***::.********* ***************************
	Human	PLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIV	120
	Mouse	AYKE----SNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNI	116
		. **    .:  **************:************:****:*:*.:. .***** :
	Human	SAEAWGRADCGFTSVSYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDF	176
	Mouse	SAEAWGRADCGITSASYQQGVLSATILYEILLGKATLYAVLVSTLVVMAMVKRKNS	172
		***********:**.****************************:**:*******:
		Polar Non-polar Positively charged Negatively charged Transmembrane segments are underlined. The alignments were generated using ClustalW