Fig 2. Heat maps showing pairwise interactions of antimicrobial treatment combinations associated with the isolation of resistant M. haemolytica organisms.

The effect of treatment with ceftiofur (CEF), danofloxacin (DANO), enrofloxacin (ENRO), florfenicol (FLOR), gamithromycin (GAM), oxytetracycline (OXY), penicillin (PEN), spectinomycin (SPEC), sulfadimethoxine (SULF), tetracycline (TET), tildipirosin (TILD), tilmicosin (TILM), tulathromycin (TUL), and tylosin (TYL) as either first (X-axis) or second (Y-axis) treatment on the frequency of isolating M. haemolytica organisms resistant to danofloxacin (A), enrofloxacin (B), florfenicol (C), spectinomycin (D), tilmicosin (E) and tulathromycin (F) was examined using CLSI interpretive criteria. White indicates no observation of antimicrobial resistance with that specific combination.