Fig. 3. Serum biomarker levels for AAV-MDR3-Aco-treated Abcb4^−/− mice through 12 weeks.

The therapeutic effect of AAV treatment is shown in males (a) and females (b & c) that were treated with AAV-MDR3-Aco at 3 × 10¹³ VG/kg one time (1×, pink, open triangles; n = 3 M (males)/1 F (females)), at 1 × 10¹⁴ VG/kg one time (1×, red, filled circles; n = 7 M/6 F), or at 1 × 10¹⁴ VG/kg two times (2×, green, filled diamonds; n = 5 F) using as controls saline-treated (blue, open squares; n = 4 M/8 F) and untreated Abcb4^+/+ (WT) mice (black, open circles; n = 3 M/3 F). Data are presented as mean + SD. ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, BS bile salts. Source data are provided as a Source Data file.