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. Author manuscript; available in PMC: 2019 Dec 14.
Published in final edited form as: ACS Infect Dis. 2019 Oct 14;5(12):2047–2054. doi: 10.1021/acsinfecdis.9b00234

Figure 1.

Figure 1.

Phylogenetic analysis and reclassification of mycobacterial Ldts based on structure, sequence, and phylogeny. A) Mycobacterial Ldts cluster into six clades that confirm five previously identified Ldt classes: class 1 (blue), class 2 (orange), class 3 (purple), class 4 (green) and class 5 (cyan). Msm LdtF clusters into a distinctive sixth clade (red). Mav = Mycobacterium avium, Mab = Mycobacterium abscessus. B) Reclassification and cartoon depiction of mycobacterial Ldts. CD = catalytic domain, BIg = bacterial Ig-like domain, R2 = Region 2 sequence (Figures S2 and S3), PRR = proline-rich region, CTSD = C-terminal subdomain, ex-CTSD = extension of the CTSD. Yellow CDs indicate the presence of Region 1 sequence (Figure S3). Class 6 Ldts contain a 10-residue insertion (red cylinder in CD). Classes 2, 5, and 6 contain an N-terminal lipobox.19 Asterisk refers to reference 19. Classes are arranged to indicate increasing apparent structural complexity.