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. 2019 Dec 13;9:19111. doi: 10.1038/s41598-019-55361-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A representation and review of data from Taleb and Betz (1994). (a) Representation of a mixed population of glycine receptors with differing EC₅₀ and n_H values derived from Fig. 2B of Taleb & Betz¹⁵. The mixed population (thick, black line) is the sum of two distinct populations (Red: I_max = 7.2 µA, EC₅₀ = 50 µM, n_H = 4.1; Blue: I_max = 20.1 µA, EC₅₀ = 289 µM, n_H = 3.1). At maximal glycine concentrations, the low EC₅₀ population conducts approximately 25% of the total current and the high EC₅₀ population conducts approximately 75% of the total current. The EC₅₀ values are sufficiently different that the mixed population has a biphasic pattern. A monophasic concentration-response model derived from such a scenario would resemble the dashed line and thus have an intermediate EC₅₀ of 194 µM, and a lower n_H of 1.7. (b) Predicted changes in overall EC₅₀ and n_H as the proportions of channels in low and high EC₅₀ states vary. The dashed line indicates the scenario depicted in Panel (a).