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. 2019 Dec 13;2:469. doi: 10.1038/s42003-019-0706-x

Fig. 1. Chemical structures of (−)-FTC-TP, (+)-FTC-TP, (−)-3TC-TP, (+)-3TC-TP, and the natural substrate deoxycytidine triphosphate (dCTP).

Fig. 1

The stereochemistry of the oxathiolane ring has an unnatural L-conformation in (−)-FTC-TP and (−)-3TC-TP as opposed to the natural D-conformation found with dCTP, (+)-3TC-TP, and (+)-FTC-TP.