Figure 2.

Unidirectional fluxes of oxalate (mucosal to serosal, ${\mathrm{J}}_{\mathit{ms}}^{\mathit{Ox}}$ and serosal to mucosal, ${\mathrm{J}}_{\mathit{sm}}^{\mathit{Ox}}$ and net flux, ${\mathrm{J}}_{\mathit{net}}^{\mathit{Ox}}$ in pmoles·cm⁻²·hr⁻¹) measured across the isolated, short-circuited distal colon removed from non-colonized PAT1 KO and in colonized PAT1 KO and PAT1/AGT dKO mice (n=7, n=7, and n=10 in each group, respectively) fed a 1.5% oxalate-supplemented diet for 12-15 days. An asterisk indicates a significant difference between groups. Transepithelial conductance G_T was comparable in all groups (G_T = 14.5 ± 1.5 mS·cm⁻² and G_T = 13.1 ± 1.2 mS·cm⁻² and G_T = 11.6 ± 0.5 mS·cm⁻² in non-colonized and colonized groups, respectively). Short-circuit current (I_sc) was also comparable in all groups (I_sc = 1.9 ± 0.3 μEq·cm⁻²·h⁻¹ and I_sc = 1.3 ± 0.2 μEq·cm⁻²·h⁻¹ and I_sc = 1.7 ± 0.2 μEq·cm⁻²·h⁻¹).