Figure 4.

Unidirectional fluxes of oxalate (mucosal to serosal, ${\mathrm{J}}_{\mathit{ms}}^{\mathit{Ox}}$ and serosal to mucosal, ${\mathrm{J}}_{\mathit{sm}}^{\mathit{Ox}}$ and net flux, ${\mathrm{J}}_{\mathit{net}}^{\mathit{Ox}}$ in pmoes·cm⁻²·hr⁻¹) measured across the isolated, short-circuited distal colon removed from non-colonized and colonized DRA KO mice (n=12 and n=9 in each group, respectively) fed a 1.5% oxalate-supplemented diet for 12-15 days. An asterisk indicates a significant difference between groups. Transepithelial conductance G_T was comparable in both groups (G_T = 11.5 ± 1.5 mS·cm⁻² and G_T = 13.0 ± 0.8 mS·cm⁻² in non-colonized and colonized groups, respectively). Short-circuit current (I_sc) was also comparable in both groups (I_sc = 1.7 ± 0.2 μEq-·cm⁻²·h⁻¹ and I_sc = 1.8 ± 0.3 μEq·cm⁻²·h⁻¹).