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. 2019 Dec 13;9:19058. doi: 10.1038/s41598-019-55533-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional integration of differentially expressed genes and target genes of differentially expressed miRNAs. (A) Histogram represents cellular pathways involved in the regulation of endothelial function obtained using differentially expressed genes (blue), and target genes of differentially expressed miRNA (yellow), identified in at least one experimental dietary study group compared to control [C57BL/6J (WT) fed control diet (CD)]. Representative integrated analysis of differentially expressed genes, and target genes of differentially expressed miRNAs for (B) adherens junctions and (C) focal adhesion pathways. Blue = differentially expressed genes; Yellow = target genes of differentially expressed miRNAs; Color gradation from Yellow to Blue = genes identified to be both differentially expressed and to be targets of differentially expressed miRNAs.