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. 2019 Dec 13;9:19029. doi: 10.1038/s41598-019-54718-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pedigree and sample information of family 1. Family 1 is a four generation family with approximately 40% individuals affected with asthma and atopy. Samples collected are marked with * symbol. Black square/circle denotes affected members while clear square/circle denotes unaffected subjects. No clear inheritance pattern could be identified from the pedigree. Interestingly, this family also has cases of consanguinity (depicted by double-lines=). Eight subjects- II:5, III:7, III:9, III:10, IV:31, IV:34, V:27, V:42 (five cases and three controls) were selected for Exome Sequencing.