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. 2019 Dec 13;9:19029. doi: 10.1038/s41598-019-54718-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Threshold tests for phenotypic correlation in Family 1, OR2AG2 levels in human lung samples and in-vitro epithelial and fibroblast cells, with or without induction with IL-13. (A) Plot showing significant decrease in mean score for odor threshold in subjects with asthma as compared to control subjects from the same family when different concentration of 2-phenylethyl alcohol (PEA) was tested (sweet odor); n = 6 control, n = 9 asthmatic subjects. (B) The bar graph represents relative mRNA expression of OR2AG2 in normal human subjects (control) and asthmatic patients (Asthma), using Real time-PCR., n = 6 asthmatics and n = 10 normal subjects. (C) The representative western blot showing a decrease in the protein level of OR2AG2 in human alveolar epithelial cell line (A549), induced with rIL-13 for 24 hours. (D) The representative western blot showing decrease in the protein level of OR2AG2 in human lung fibroblast cells (HFL1), induced with rIL-13 for 24 hours. (E,F) Densitometric quantification of the experiment performed in (C,D) respectively, values are normalized to α-tubulin levels. All results are expressed as the mean ± SEM. *P < 0.05 and **P < 0.01 (t-test).