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. 2019 Dec 13;9:19061. doi: 10.1038/s41598-019-55503-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aging mice are characterized by differential antibodies and cytokine response. (A) Sera from mice at indicated times was tested for antibodies to Vimentin, Fibrinogen and atrial natriuretic peptide (ANP); Vimentin and ANP, *0402 young vs old P < 0.05, ANP old *0401 vs *0402, P < 0.02, Vimentin, old *0401 vs *0402, P < 0.08. Control young AEo vs *0401 and *0402 mice for Vimentin and ANP, P < 0.02 and old AEo vs *0402 for Vimentin and ANP, P < 0.01 (N = 4–6/group). Sera cytokines at indicated ages in naive mice (N = 5–6/strain/time point). *0401 vs *0402, *P < 0.04, **P < 0.005, ^#P < 0.05.