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. 2019 Dec 13;10:5693. doi: 10.1038/s41467-019-13674-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a T-SDRs/SDWs positioning relative to the instable regions. OK-Seq, Repli-Seq and GRO-Seq profiles, and T-SDRs/SDWs (presented as in Fig. 2c) are shown along regions hosting the indicated genes/CFSs. These sites were chosen, because they display a break frequency ≥ 1% in normal lymphocytes³² and have been fine-mapped by FISH (black bars) in lymphocytes¹⁹. The T-SDRs/SDWs are included in, or at least partially overlap, the instable regions. The genomic regions displayed are as follows: chr2:17.8-20.6 Mb; chr2:14.7-16.3 Mb; chr2:186.4-187.9 Mb; chr7:109.8-111.5 Mb; chr13:34.9-37 Mb; chrX:6.2-8.9 Mb. b T-SDRs positioning relative to the instable regions hosting FHIT/FRA3B and WWOX/FRA16D relative to the URI profiles. The genes, URI profiles, T-SDRs/SDWs and instable regions mapped by FISH are presented as in a. Source data are provided as a Source Data file.