Table 1.
Basal characteristics and stimulation outcomes of the studied populations
| Demographic data of study population | ||||||
|---|---|---|---|---|---|---|
| PGT-A | Drop-out | Control | P value | |||
| PGT-A vs drop-out | PGT-A vs control | Drop-out vs control | ||||
| No. of patients | 269 | 101 | 2168 | |||
| No. of cycles | 308 | 106 | 2905 | |||
| Mean female age (SD) | 40.4 (± 3.3) | 41.1 (± 3.0) | 39.7 (± 2.4) | P = 0.047 | P < 0.001 | P = 0.001 |
| BMI female | 21.9 (± 3.0) | 21.8 (± 3.0) | 22.4 (± 3.3) | NS | NS | NS |
| Duration of infertility, months (SD) | 57 (± 32.7) | 53 (± 36.4) | 51 (± 31.8) | NS | P = 0.004 | NS |
| FSH (mIU/mL) | 7.3 (± 2.3) | 8 (± 3.0) | 7.4 (± 2.5) | P = 0.017 | NS | P = 0.020 |
| AMH (ng/mL) | 2.7 (± 2.1) | 1.8 (± 1.7) | 2.4 (± 2.9) | P < 0.001 | NS | P = 0.039 |
| Indication to PGT-A per cycle | ||||||
| AMA (%) | 124/308 (40.3%) | 48/106 (45.3%) | NS | |||
| AMA + RIF (%) | 128/308 (41.6%) | 28/106 (26.4%) | P = 0.006 | |||
| AMA + RPL (%) | 49/308 (15.9%) | 28/106 (26.4%) | P = 0.016 | |||
| AMA + RIF+ RPL (%) | 6/308 (1.9%) | 1/106 (0.9%) | NS | |||
| AMA + other (%) | 1/308 (0.3%) | 1/106 (0.9%) | NS | |||
| Indication for infertility treatment per cycle | ||||||
| Male Factor | 71/308 (23.05%) | 15/106 (14.1%) | 823/2905 (28.3%) | NS | P = 0.049 | P = 0.001 |
| Idiopathic | 73/308 (23.7%) | 18/106 (17.0%) | 376/2905 (12.9%) | NS | P < 0.001 | NS |
| Mixed male and female factors | 53/308 (17.21%) | 26/106 (24.5%) | 713/2905 (24.5%) | NS | P = 0.004 | NS |
| Poor ovarian reserve | 41/308 (13.32%) | 26/106 (24.5%) | 466/2905 (16.0%) | P = 0.007 | NS | P = 0.020 |
| Recurrent miscarriage | 32/308 (10.39%) | 6/106 (5.7%) | 17/2905 (0.6%) | NS | P < 0.001 | P < 0.001 |
| Multiple female factors | 15/308 (4.87%) | 6/106 (5.7%) | 171/2905 (5.9%) | NS | NS | NS |
| Tubal factor | 14/308 (4.54%) | 4/106 (3.8%) | 230/2905 (7.9%) | NS | P = 0.034 | NS |
| Endometriosis | 6/308 (1.95%) | 3/106 (2.8%) | 70/2905 (2.4%) | NS | NS | NS |
| Abnormal ovulation | 3/308 (0.97%) | 2/106 (1.9%) | 39/2905 (1.3%) | NS | NS | NS |
| Protocol per cycle | ||||||
| Antagonist | 255/308 (82.8%) | 81/106 (76.5%) | 2235/2905 (76.9%) | NS | NS | NS |
| Flare-up | 9/308 (2.9%) | 12/106 (11.3%) | 290/2905 (10%) | P = 0.001 | P < 0.001 | NS |
| Agonist | 44/308 (14.3%) | 13/106 (12.3%) | 380/2905 (13.1%) | NS | NS | NS |
| Semen | ||||||
| Ejaculated (%) | 284/308 (92.2%) | 97/106 (91.5%) | 2609/2905 (89.8%) | NS | NS | NS |
| Surgical (%) | 24/308 (7.8%) | 9/106 (8.5%) | 296/2905 (10.2%) | NS | NS | NS |
| Stimulation outcome | ||||||
| Mean aspirated follicles (SD) | 13.4 (± 6.2) | 7.9 (± 4.4) | 12.8 (± 5.3) | P = 0.001 | NS | P = 0.001 |
| Mean retrieved oocyte (SD) | 10.9 (± 5.8) | 6.6 (± 4.1) | 10.2 (± 5.0) | P = 0.001 | P = 0.021 | P = 0.001 |
| Mean mature oocytes (SD) | 8.3 (± 4.1) | 4.6 (± 3.0) | 7.9 (± 3.7) | P = 0.001 | NS | P = 0.001 |