Table 3.
Treatment outcomes of study subgroups
| Cumulative clinical outcomes of PGT-A group and day 3/day 5 control group | ||||||
|---|---|---|---|---|---|---|
| PGT-A | Control day 5 | Control day 3 | P value | |||
| PGT-A vs control (day 5 only) | PGT-A vs control (day 3 only) | Day 5 only vs day 3 only | ||||
| Embryo transfers | 201 | 1147 | 2426 | |||
| Transferred embryos (mean; ± SD) | 201 (1 ± 0) | 1188 (1.04 ± 0.19) | 5185 (2.14 ± 0.53) | P = 0.013 | P < 0.001 | P < 0.001 |
| Positive βhCG per transfer (%) | 93/201 (46.3%) | 433/1147 (37.7%) | 679/2426 (28.0%) | P = 0.023 | P < 0.001 | P < 0.001 |
| Biochemical pregnancy per βhCG + ve (%) | 5/93 (5.4%) | 31/433 (7.2%) | 53/679 (7.8%) | NS | NS | NS |
| Ongoing implantation (%)§ | 84/201 (41.8%) | 355/1188 (29.9%) | 651/5185 (12.55%) | P = 0.001 | P < 0.001 | P < 0.001 |
| Ongoing clinical pregnancy per transfer (%) | 84/201 (41.8%) | 350/1147 (30.5%) | 552/2426 (22.8%) | P = 0.002 | P < 0.001 | P < 0.001 |
| Multiple pregnancy rate (%) | 0/84 (0.0%) | 5/350 (1.4%) | 95/552 (17.2%) | NS | P < 0.001 | P < 0.001 |
| Overall clinical pregnancy loss (%) | 3/84 (3.6%) | 82/350 (23.4%) | 122/552 (22.1%) | P < 0.001 | P < 0.001 | NS |
| Miscarriages < 12 week (%) | 2/84 (2.4%) | 63/350 (18.0%) | 89/552 (16.1%) | P < 0.001 | P < 0.001 | NS |
| Miscarriages > 12 week (%) | 0/84 (0.0%) | 16/350 (4.6%) | 19/552 (3.4%) | P = 0.05 | NS | NS |
| Therapeutic abortion (%) | 0/84 (0.0%) | 2/350 (0.6%) | 11/552 (2.0%) | NS | NS | NS |
| Ectopic pregnancies (%) | 1/84 (1.2%) | 1/350 (0.3%) | 3/552 (0.5%) | NS | NS | NS |
| Aneuploid pregnancy per POC or prenatal screening test (%)♯ | 0/24 (0.0%)° | 17/117 (14.5%) | 34/203(16.7%) | P = 0.046 | P = 0.030 | NS |
| Delivery per ongoing clinical pregnancy (%) | 81/84 (96.4%) | 268/350 (76.6%) | 430/552 (77.9%) | P < 0.001 | P < 0.001 | NS |
| Singleton delivery (%) | 81/81 (100%) | 264/268 (98.5%) | 359/430 (83.5%) | NS | P < 0.001 | P < 0.001 |
| Twin delivery (%) | 0/81 (0.0%) | 4/268 (1.5%) | 69/430 (16.0%) | NS | P < 0.001 | P < 0.001 |
| Triplet delivery (%) | 0/81 (0.0%) | 0/268 (0.0%) | 2/430 (0.5%) | NS | NS | NS |
| Total multiple delivery (%) | 0/81 (0.0%) | 4/268 (1.5%) | 71/430 (16.5%) | NS | P < 0.001 | P < 0.001 |
| Outcome summary, delivery | ||||||
| Per embryo transfer (%) | 81/201 (40.3%) | 268/1147 (23.4%) | 430/2426 (17.7%) | P < 0.001 | P < 0.001 | P < 0.001 |
| Per βhCG (%) | 81/93 (87.1%) | 268/433 (61.9%) | 430/679 (63.3%) | P < 0.001 | P < 0.001 | NS |
| Per ongoing clinical pregnancy (%) | 81/84 (96.4%) | 268/350 (76.6%) | 430/552 (77.9%) | P < 0.001 | P < 0.001 | NS |
§Sacs with FHB/transferred embryos
♯Calculated on prenatal and POC analyses available
°One aneuploid pregnancy identified in the group removed due to spontaneous conception (Bettio et al., 2016)