KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Topo IIB	Santa Cruz	Cat#SC-48429; RRID:AB_628383
GAPDH	Santa Cruz	Cat#SC-25778; RRID:AB_10167668
UCP1	Abcam	Cat#ab10983; RRID:AB_2241462
FLAG	Cell signaling	Cat#14793S; RRID:AB_2572291
Zc3h10 (Immunoblotting)	ThermoFisher	Cat#PA5-31814; RRID:AB_2549287
Zc3h10 (ChIP)	Abnova	Cat#H00084872-B01P; RRID:AB_1643833
P-S126 Zc3h10	Genemed Synthesis Inc.	N/A
ATF2	Cell signaling	Cat#35031; RRID:AB_2799069
P-ATF2	Abcam	Cat#ab32019; RRID:AB_725567
Phosphoserine	Millipore	Cat#ab1603; RRID:AB_390205
Bacterial and Virus Strains
Ad-Zc3h10-flag	ViraQuest	N/A
Ad-Zc3h10-shRNA	Vector Biolabs	Cat#shADV-276549
Chemicals, Peptides, and Recombinant Proteins
MitoTracker Green	Cell signaling	Cat#9074
LipidTox Red Reagent	ThermoFisher	Cat#H34476
Duolink Mounting medium with DAPI	Sigma-Aldrich	Cat#DUO82040
CL-316,243	Sigma-Aldrich	Cat#C5976
SB203580	Sigma-Aldrich	Cat# S8307
Critical Commercial Assays
LightShift Chemiluminescent EMSA Kit	Thermofisher	Cat#20148
SimpleChIP kit	Cell Signaling	Cat##56383
Mitochondria Isolation Kit for Tissue	Thermofisher	Cat#89801
NE-PER Nuclear and Cytoplasmic Extraction kit	ThermoFisher	Cat#78833
Dual-Luciferase Kit	Promega	Cat#E1980
Deposited Data
Raw and analyzed data	This paper	GEO: GSE139029
Experimental Models: Cell Lines
3T3-L1	UCB Cell Culture Facility	N/A
HEK293FT	UCB Cell Culture Facility	N/A
Experimental Models: Organisms/Strains
Mouse: AQ-Zc3h10	This Laboratory	N/A
Mouse: AQ-Zc3h10-mutZfp1/2	This Laboratory	N/A
Mouse: UCP1-Cre B6.FVB-Tg(Ucp1-cre)1Evdr/J	The Jackson Laboratory	024670
Oligonucleotides
See Table S1 for RT-qPCR and ChIP primers		N/A
See Table S2 for gel shift probes		N/A
Recombinant DNA
pCMV-3Tag3A	Agilent	Cat#240195
pGEX-4T-3	GE Healthcare	Cat#28-9545-52
Software and Algorithms
MACS	Zhang et al., 2008	https://github.com/taoliu/MACS/
GREAT	McLean et al., 2010	http://great.stanford.edu/public/html/
MEME	Bailey and Elkan, 1994	http://meme-suite.org/tools/meme