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. 2019 Nov 18;116(50):25311–25321. doi: 10.1073/pnas.1905787116

Fig. 6.

Fig. 6.

Probiotic VSL#3 enhances the onset of inflammation following demyelination. (A) The 13-mo-old mice were administered 1.35 × 109 CFU VSL#3 daily for 1 mo by oral gavage. Mice were killed at 5 and 14 d following lysolecithin injection into the ventral white matter of the spinal cord. (B) Constituent strains of VSL#3. (C) Representative images and (D) density of CD68hi activated microglia/macrophages within lesions. (E) Representative images and density of (F) Tmem119+CD68hi microglia-derived and (G) Tmem119−CD68hi monocyte-derived CD68hi cells within lesions. (H) Representative images and density of (I) P2ry12hiClec7a− homeostatic and (J) P2ry12loClec7a+ degeneration-associated microglia/macrophages within lesions. Insets in E and H are a 3× magnification of the boxed regions. (Scale bars: C, 250 μm; E and H, 200 μm, and Insets, 25 μm.) Error bars show mean ± SEM; *P < 0.05; Student’s t test, n = 3 to 5 mice.